University of Pittsburgh Department of Cell Biology

  • Research

    The Vargas Lab researches alpha-synuclein in hopes to find clues that can be used to generate new therapies for Parkinson's disease and other neurodegenerative diseases

  • Publications

    1. Vargas KJ, Colosi PL, Girardi E, Park JM, Harmon LE, Chandra SS. α-Synuclein colocalizes with AP180 and affects the size of clathrin lattices.. J Biol Chem. 2023 Jul 27;():105091. doi: 10.1016/j.jbc.2023.105091. PubMed PMID: 37516240;
    2. Soll LG, Eisen JN, Vargas KJ, Medeiros AT, Hammar KM, Morgan JR. α-Synuclein-112 Impairs Synaptic Vesicle Recycling Consistent With Its Enhanced Membrane Binding Properties.. Front Cell Dev Biol. 2020;8():405. doi: 10.3389/fcell.2020.00405. PubMed PMID: 32548120;
    3. Vargas KJ. Kinetic Measurements of Endocytosis and Exocytosis in Cultured Neurons.. Methods Mol Biol. 2019;1948():23-33. doi: 10.1007/978-1-4939-9124-2_3. PubMed PMID: 30771167;
    4. Vargas KJ, Schrod N, Davis T, Fernandez-Busnadiego R, Taguchi YV, Laugks U, Lucic V, Chandra SS. Synucleins Have Multiple Effects on Presynaptic Architecture.. Cell Rep. 2017 Jan 3;18(1):161-173. doi: 10.1016/j.celrep.2016.12.023. PubMed PMID: 28052246;
    5. Vargas KJ, Makani S, Davis T, Westphal CH, Castillo PE, Chandra SS. Synucleins regulate the kinetics of synaptic vesicle endocytosis.. J Neurosci. 2014 Jul 9;34(28):9364-76. doi: 10.1523/JNEUROSCI.4787-13.2014. PubMed PMID: 25009269;

     

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