University of Pittsburgh Department of Cell Biology
    • Jay Tan, Ph.D.

    Jay Tan, Ph.D.

    Research Assistant Professor
    Tel: 412-383-4405
    Fax:
    Address: 513 Bridgeside Point I, 100 Technology Drive, Pittsburgh 15219
    jay.tan@pitt.edu
  • Research

    Aging is a combined consequence of increased cellular stress and decreased homeostasis. Our research focuses on basic molecular mechanisms underlying cell homeostasis and stress response. Currently, we are aiming at discovering the molecular mechanisms underlying the sensing, repairing, and clearance of damaged organelles in mammalian cells. We believe there is a unifying principle behind these complex stress response processes and that spatiotemporal lipid signaling is one such general principle. Our long- term goal is to identify the molecular basis of aging with a focus on lipid signaling and to develop pharmacological strategies to fight aging and age-related diseases.
  • Publications

    1. Gui X, Yang H, Li T, Tan X, Shi P, Li M, Du F, Chen ZJ. Autophagy induction via STING trafficking is a primordial function of the cGAS pathway.. Nature. 2019 Mar;567(7747):262-266. doi: 10.1038/s41586-019-1006-9. PubMed PMID: 30842662;
    2. Tan X, Sun L, Chen J, Chen ZJ. Detection of Microbial Infections Through Innate Immune Sensing of Nucleic Acids.. Annu Rev Microbiol. 2018 Sep 8;72():447-478. doi: 10.1146/annurev-micro-102215-095605. PubMed PMID: 30200854;
    3. Tan X, Anderson RA. Keeping in touch with the ER network.. Science. 2017 May 12;356(6338):584-585. doi: 10.1126/science.aan4807. PubMed PMID: 28495716;
    4. Thapa N, Tan X, Choi S, Lambert PF, Rapraeger AC, Anderson RA. The Hidden Conundrum of Phosphoinositide Signaling in Cancer.. Trends Cancer. 2016 Jul;2(7):378-390. . PubMed PMID: 27819060;
    5. Tan X, Thapa N, Liao Y, Choi S, Anderson RA. PtdIns(4,5)P2 signaling regulates ATG14 and autophagy.. Proc Natl Acad Sci U S A. 2016 Sep 27;113(39):10896-901. doi: 10.1073/pnas.1523145113. PubMed PMID: 27621469;
    6. Thapa N, Tan X, Choi S, Wise T, Anderson RA. PIPKIγ and talin couple phosphoinositide and adhesion signaling to control the epithelial to mesenchymal transition.. Oncogene. 2017 Feb 16;36(7):899-911. doi: 10.1038/onc.2016.267. PubMed PMID: 27452517;
    7. Tan X, Lambert PF, Rapraeger AC, Anderson RA. Stress-Induced EGFR Trafficking: Mechanisms, Functions, and Therapeutic Implications.. Trends Cell Biol. 2016 May;26(5):352-366. doi: 10.1016/j.tcb.2015.12.006. PubMed PMID: 26827089;
    8. Tan X, Thapa N, Choi S, Anderson RA. Emerging roles of PtdIns(4,5)P2--beyond the plasma membrane.. J Cell Sci. 2015 Nov 15;128(22):4047-56. doi: 10.1242/jcs.175208. PubMed PMID: 26574506;
    9. Tan X, Thapa N, Sun Y, Anderson RA. A kinase-independent role for EGF receptor in autophagy initiation.. Cell. 2015 Jan 15;160(1-2):145-60. doi: 10.1016/j.cell.2014.12.006. PubMed PMID: 25594178;
    10. Tan X, Sun Y, Thapa N, Liao Y, Hedman AC, Anderson RA. LAPTM4B is a PtdIns(4,5)P2 effector that regulates EGFR signaling, lysosomal sorting, and degradation.. EMBO J. 2015 Feb 12;34(4):475-90. doi: 10.15252/embj.201489425. PubMed PMID: 25588945;
    11. Sun Y, Hedman AC, Tan X, Anderson RA. An unexpected role for PI4,5P 2 in EGF receptor endosomal trafficking.. Cell Cycle. 2013 Jul 1;12(13):1991-2. doi: 10.4161/cc.25309. PubMed PMID: 23759577;
    12. Sun Y, Hedman AC, Tan X, Schill NJ, Anderson RA. Endosomal type Iγ PIP 5-kinase controls EGF receptor lysosomal sorting.. Dev Cell. 2013 Apr 29;25(2):144-55. doi: 10.1016/j.devcel.2013.03.010. PubMed PMID: 23602387;

     

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