The extraordinarily emergent properties of living cells have evolved largely as a consequence of the intricately ordered interactions of their biomolecular components. These cellular building blocks interact with each other to form a hierarchy of dynamic macromolecular assemblies that drive a plethora of intriguing biological processes. Unfortunately, despite their central role in cell biology, many of the macromolecular complexes identified to date remain refractory to structure-functional characterization.
Our lab is interested in the development of cutting-edge mass spectrometry-based proteomic technologies. We are also interested in elucidating the structure- functions of native macromolecular assemblies and dissecting intriguing biological pathways that regulate DNA damage response and autophagy by using multidisciplinary approaches including proteomics, cell biology, and biophysics.