University of Pittsburgh Department of Cell Biology
    • Joseph M. Pilewski, M.D.

    Joseph M. Pilewski, M.D.

    Associate Professor
    Medicine, Pulmonary, Allergy and Critical Care Medicine
    Tel: 412-647-8477
    Fax: 412-692-2260
    Address: NW628 MUH
    pilewskijm@upmc.edu

    External Lab Website

  • Research

    Dr. Pilewski's clinical interests include cystic fibrosis, chronic airway diseases, and critical illness. His research interests include the pathogenesis and development of new treatments for cystic fibrosis, and gene therapy for lung diseases. He has established a research program within the Cystic Fibrosis (CF) Research Development Program at the University of Pittsburgh and Children's Hospital of Pittsburgh. He has secondary appointments in pediatrics, and cell biology and physiology.

  • Publications

    1. Carattino MD, Passero CJ, Steren CA, Maarouf AB, Pilewski JM, Myerburg MM, Hughey RP, Kleyman TR. Defining an inhibitory domain in the alpha-subunit of the epithelial sodium channel. Am J Physiol Renal Physiol. 2008 Jan;294(1):F47-52. Epub 2007 Nov 21.
    2. Myerburg MM, McKenna EE, Luke CJ, Frizzell RA, Kleyman TR, Pilewski JM. Prostasin expression is regulated by airway surface liquid volume and is increased in cystic fibrosis. Am J Physiol Lung Cell Mol Physiol. 2008 Feb 29; [Epub ahead of print]
    3. Bruns JB, Carattino MD, Sheng S, Maarouf AB, Weisz OA, Pilewski JM, Hughey RP, Kleyman TR. Epithelial Na+ channels are fully activated by furin- and prostasin-dependent release of an inhibitory peptide from the gamma-subunit. J Biol Chem. 2007 Mar 2;282(9):6153-60. Epub 2007 Jan 1.
    4. Myerburg MM, Latoche JD, McKenna EE, Stabile LP, Siegfried JS, Feghali-Bostwick CA, Pilewski JM. Hepatocyte growth factor and other fibroblast secretions modulate the phenotype of human bronchial epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2007 Jun;292(6):L1352-60. Epub 2007 Feb 16.

     

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