Inherited mutations in ion channels are responsible for many genetic diseases, including cystic fibrosis (CF). The department is home to a Specialized Center of Research in CF funded by the NIH (one of only two in the country) and the CF Foundation. Here, scientists are defining the factors that regulate ion channel activity and their expression on the plasma membrane. Inherited disorders of ion channels beyond CF include chronic obstructive pulmonary disease and hypertension. Program scientists are using biochemical, molecular expression, electrophysiologic, cell biologic and transgenic techniques to identify the channels involved in these processes and to define their regulation. Dr. Salama is using molecular engineering of ion channels and high-speed imaging to study the mechanisms responsible for the initiation and termination of cardiac arrhythmias.

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