Research interests in my laboratory focus on the role of ubiquitin-dependent proteolysis in biological regulation. Currently, we are studying the control of cell cycle progression by proteolytic regulation. We are also interested in investigating the role of proteolysis in the regulation of the DNA damage-repair process, in the renewal and differentiation of stem cells, and in the pathogenesis of tumor formation. The long-term goal is to understand the biochemistry of these protein degradation pathways and to develop new intervention strategies based on an understanding of proteolytic regulation to combat cancer and treat other human disease. To achieve this, we plan to develop mutidisciplinary approaches, including biochemical and genetic analyses as well as chemical genetic techniques. We will apply these methods using several systems including functional proteomics, mammalian tissue culture, and mouse model systems.