Patricia A. Hebda, Ph.D.
Research Associate Professor
Primary Appointment: Otolaryngology
Tel: 412-692-6217
Fax: 412-692-5075
hebda@pitt.edu
PubMed pub. listing
Hebda Webpage
CBP Research Group(s):
CBMP Grad. Program Group: Cellular Injury and Wound Healing

Research Interest

Dr. Hebda's fundamental purpose is to develop new, biologically driven therapeutic modalities to promote and optimize wound healing of the upperaerodigestive system. In order to achieve this goal, we have projects based on:

The applicaton of molecular biology to analyze fetal vs adult wound healing, tissue engineering of soft and hard connective tissues of the upperaerodigestve tract, and development of animal and tissue culture models to undertand the mechanisms of ideal tissue repair.

Although wound healing research has been extensively explored in the skin, very little work has been done to investigate mucosal wound healing. The field of otolaryngology presents numerous clinical scenarios of problematic wound healing including subglottic stenosis, chronic suppurative otitis media, and sinusitis. With the exploration of the fetal wound environment, which heals without scarring, and using the powerful tools of molecular biology, there is the potential for new far-reaching insight into biological therapies for optimizing the course of wound healing of the mucosa, the skin and other organs and tissues.

We have a number of ongoing clinical and basic science projects in which a hightly motivated student can become involved. The environment and resources in Pediatric Otolaryngology are extremely supportive of research endeavors.

Publications
  1. Hebda PA, Whaley D, Kim HG, Wells A. Absence of inhibition of cutaneous wound healing in mice by oral doxycycline. Wound Repair Regen. 2003 Sep-Oct;11(5):373-9.
  2. Li HS, Doyle WJ, Swarts JD, Lo CY, Hebda PA. Mucosal expression of genes encoding possible upstream regulators of Na+ transport during pneumococcal otitis media. Acta Otolaryngol. 2003 Jun;123(5):575-82.
  3. Mandell DL, Devor DC, Madia JV, Lo CY, Hake H, Hebda PA. The effect of changes in ambient oxygen concentration on the bioelectric properties of middle ear mucosa. Am J Physiol Cell Physiol. 2003 Sep;285(3):C618-22. Epub 2003 May 21.
  4. Sandulache VC, Zhou Z, Sherman A, Dohar JE, Hebda PA. Impact of transplanted fibroblasts on rabbit skin wounds. Arch Otolaryngol Head Neck Surg. 2003 Mar;129(3):345-50.
  5. Verdolini K, Rosen CA, Branski RC, Hebda PA. Shifts in biochemical markers associated with wound healing in laryngeal secretions following phonotrauma: a preliminary study. Ann Otol Rhinol Laryngol. 2003 Dec;112(12):1021-5.
  6. Alper CM, Bluestone CD, Buchman C, Bunne M, Felding JU, Hebda PA, Hergils L, Honjo I, Luntz M, Sando I, Stangerup SE, Swarts JD, Takahashi H. Recent advances in otitis media. 3. Middle ear physiology and pathophysiology. Ann Otol Rhinol Laryngol Suppl. 2002 Mar;188:26-35. Review.
  7. Hebda PA, Burckar GJ, Alper CM, Swarts JD, Moody-Antonio S, Zeevi A, Doyle WJ. Effect of 10 pharmacologic probes on mRNA levels of inducible nitric oxide synthetase and selected inflammatory cytokines in a rat model of acute otitis media. Acta Otolaryngol. 2002 Apr;122(3):255-61.
  8. Hebda PA, Piltcher OB, Swarts JD, Alper CM, Zeevi A, Doyle WJ. R Cytokine profiles in a rat model of otitis media with effusion caused by eustachian tube obstruction with and without Streptococcus pneumoniae infection. Laryngoscope. 2002 Sep;112(9):1657-62.
  9. Li HS, Doyle WJ, Swarts JD, Hebda PA. Suppression of epithelial ion transport transcripts during pneumococcal acute otitis media in the rat. Acta Otolaryngol. 2002 Jul;122(5):488-94.
  10. Piltcher OB, Swarts JD, Magnuson K, Alper CM, Doyle WJ, Hebda PA. A rat model of otitis media with effusion caused by eustachian tube obstruction with and without Streptococcus pneumoniae infection: methods and disease course. Otolaryngol Head Neck Surg. 2002 May;126(5):490-8.