Selected Publications

  1. Liu W., Wu G., Lobur D., Li W., and Wan Y. 2007. Cdh1-APC targets Skp2 for destruction in TGF-β-induced growth inhibition. Mol Cell Biol. Vol.27 (8): 2967-79

  2. Wu G., Glickstein S., Liu W, Fujita T., Li W., Yang Q., Duvoisin R., and Wan Y. 2007. The APC coordinates the initiation of lens differentiation. Mol Biol Cell. Vol 18 (3): 1018-29

  3. Li W., Wu G., and Wan Y. 2007. The dual effects of Cdh1 in myogenesis. FASEB J. 21(13): 3606-17

  4. Liu W., Li W., Fujita T., Yang Q., and Wan Y. 2008. Proteolysis of Cdh1 enhances susceptibility to UV radiation-induced apoptosis. Carcinogenesis (Epub ahead of print)

  5. Fujita T. Liu W., Hiroyoshi D. and Wan Y. 2008. Dissection of APC pathway in breast cancer. Clin Cancer Res (Epub ahead of print)
     
  6. Fujita T., Hiroyoshi D. and Wan Y. 2008. Regulation of Skp2-p27 axis by the Cdh1/APC pathway in colorectal tumorigenesis.  Am J. Pathol. (in press)

  7. Liu W., Zong W., Wu G., Fujita T., Li W., Wu J. and Wan Y. 2008. BRCA1 is regulated by ubiquitin-proteasome pathway in response to DNA damage signaling. (revision)

  8. Fujita T., Epperly M.W., Zou H., Gollin S.M., Greenberger, J.S. and Yong Wan. 2008. Targeting APC-separase cascade by TGF-β ensures mitotic progression. (revision)

  9. Fujita T., Liu W., Doihara H. and Wan Y. 2008. In vivo dissection of Cdh1/APC in breast carcinogenesis (revision)

  10. Wei W*, Ayad NG*, Wan Y, Zhang GJ, Kirschner MW, Kaelin WG Jr. 2004. Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase-promoting complex. Nature 428:194-8.

  11. Macdonald M., Wan Y., Wang W., Roberts B., Cheung T., Erickson R., Kirschner M. W. and Liu X. 2004. Cdc34 is required for cell cycle dependent degradation of c-Ski proto-oncoprotein. Oncogene 23(33): 5643-53

  12. Knuesel MP, Wan Y, Xia Z, Holinger EP, Lowe N, Wang W, Liu X. 2003. Identification of novel protein-protein interactions using a versatile mammalian TAP expression system. MCP (11): 1225-33

  13. Wan Y., Liu X. and Kirschner W. M. 2001. The anaphase-promoting complex mediates TGF-β signaling by targeting SnoN for destruction. Molecular Cell 8(5): 1027-1039.

  14. Wan Y. and Kirschner W. M. 2001. Identification of multiple CDH1 homologues in vertebrates conferring different substrate specificities. Proc. Natl. Acad. Sci. USA 98: 13066-13071.

  15. Jiang Y., Ma W., Wan Y., Kozasa T., Hassatli T., and Huang X-Y. 1998. Gα12 directly stimulates a tyrosine kinase and a Ras-Gap through conserved PH-BM domain. Nature 395: 808-813.

  16. Wan Y. and Huang X-Y. 1998. Analysis of the Gs/mitogen-activated protein kinase pathway in mutant S49 cells. J. Biol. Chem. 273: 14533-14537.

  17. Wan Y., Bence K., Hata A., Kurosaki T. Veillette A., and Huang X-Y . 1997. Genetic evidence for a tyrosine kinase cascade preceding the mitogen-activated protein kinase cascade in vertebrate G-protein signaling. J. Biol. Chem. 272: 17209-17215.

  18. Wan Y., Kurosaki T., and Huang X-Y. 1996.  Tyrosine kinases in activation of the MAP kinase cascade by G-protein-couple receptors. Nature 380: 541-544.

  19. Langhans-Rajasekaran S., Wan Y., and Huang X-Y.  1995. Activation of Tsk and Btk tyrosine kinases by G protein βγ subunits. Proc. Natl. Acad. Sci. USA . 92: 8601-8605.