I am interested in the molecular mechanisms of endosomal trafficking and membrane remodeling, and how these highly complex processes are integrated into the TORC1 signaling network. The primary model I utilize is the budding yeast Saccharomyces cerevisiae. Membrane remodeling processes are integral to endosomal morphology, function in cargo sorting and trafficking. I focus on a set of proteins involved in membrane remodeling. These include the dynamin-related proteins, the sorting nexins and retromer. I combine structural approaches with live-cell imaging and classical yeast genetics and molecular biology. Recently, membrane remodeling has also emerged as a key regulator of signaling by TORC1, the master controller of cell growth decisions in all eukaryotic cells. Using high-throughput genetics, in-vivo imaging and biochemistry, I am dissecting the signaling pathways regulating TORC1 rEsponses to starvation.