Dr. Sun's research is focused on the regulation of protein processing in the endoplasmic reticulum (ER). His primary interest is to elucidate the mechanism(s) for CFTR folding and processing in the ER and to biochemically alter the processing. He is interested in the protein-protein interactions between CFTR and molecular chaperones, such as Hsp70, Hsc70 and Hdj2. His interest also lies in functional proteomics to study protein processing. Techniques used include: molecular biology, protein chemistry, electrophysiological techniques and adenoviral or peptide-mediated gene transfer.
Publications
Sun F, Zhang R, Gong X, Geng X, Drain PF, Frizzell RA. (2006) Derlin-1 promotes the efficient degradation of the cystic fibrosis transmembrane conductance regulator (CFTR) and CFTR folding mutants. J Biol Chem. 281(48):36856-63
Zhang H, Schmidt BZ, Sun F, Condliffe SB, Butterworth MB, Youker RT, Brodsky JL, Aridor M, Frizzell RA. (2006) Cysteine string protein monitors late steps in cystic fibrosis transmembrane conductance regulator biogenesis. J Biol Chem. 281(16):11312-21
Zhang, H., Peters, KW., Sun, F., Marino CR, Lang J, Burgoyne RD, Frizzell RA.. (2002) Cysteine string protein interacts with and modulates the maturation of the cystic fibrosis transmembrane conductance regulator Journal of Biological Chemistry 277(32): 28948-58
Sun, F., Hug, MJ., Bradbury, NA., and Frizzell, RA.. (2000) Protein kinase A associates with CFTR via an interaction with ezrin. Journal of Biological Chemistry 275 (19): 14360-14366
Sun, F., Hug, MJ., Lewarchik CM., Yun, CH., Bradbury, NA., and Frizzell, RA.. (2000) E3KARP mediates the association of ezrin and protein kinase A with cystic fibrosis transmembrane conductance regulator in airway cells Journal of Biological Chemistry 275 (38): 29539-29546
