Physical Molecular Biology Section
University of Pittsburgh Laboratory of Physical Molecular Biology; Sanford Leuba, Ph.D.
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Modeling of the Effect of the Removal of Linker Histone from Chromatin Fibers
   
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A. A Computer-generated Model of a
Linker Histone-depleted Chromatin Fiber.		B. Simulated SFM Image of the Fiber in
"A"
C. Experimental SFM Image
of Glutaraldehyde-fixed,
H1/H5-depleted Chromatin Fiber
Simulated and Experimental SFM Images of Linker Histone-depleted Chromatin Fibers.

Linker histones appear to play a role in the three-dimensional structure of the fiber by helping maintain the DNA entry/exit angle.