Physical Molecular Biology Section
University of Pittsburgh Laboratory of Physical Molecular Biology; Sanford Leuba, Ph.D.
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Modeling of the Effect of the Removal of Linker Histone from Chromatin Fibers
University of Pittsburgh Home University of Pittsburgh School of Medicine Pitt SOM Department of Cell Biology and Physiology Read a bio of Sanford Leuba, Ph.D.
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A. A Computer-generated Model of a
Linker Histone-depleted Chromatin Fiber.
B. Simulated SFM Image of the Fiber in
C. Experimental SFM Image
of Glutaraldehyde-fixed,
H1/H5-depleted Chromatin Fiber
Simulated and Experimental SFM Images of Linker Histone-depleted Chromatin Fibers.

Linker histones appear to play a role in the three-dimensional structure of the fiber by helping maintain the DNA entry/exit angle.