To understand the mechanisms governing the migration of intestinal epithelial cells during conditions of intestinal inflammation, such as necrotizing enterocolitis, Crohn's disease and infection. This information will hopefully provide novel therapeutic targets for treating these disorders.
To understand the mechanisms of phagocytosis of pathogens by macrophages in neonates during conditions of inflammation. This information will hopefully provide insights for enhancing the immune system during critical illness.
Initiating a large review of all patients with congenital diaphragmatic hernia to determine the optimal timing and mode of surgical repair.
Initiating a retrospective and prospective review of patients with tracheo-esophageal fistula to determine the factors influencing outcome in these patients.
Retrospective review of patients who have sustained traumatic intestinal injuries, to determine the optimal diagnostic modality and to determine strategies to improve their outcome.
Publications
Anand RJ, Dai S, Rippel C, Leaphart C, Qureshi F, Gribar SC, Kohler JW, Li J, Beer Stolz D, Sodhi C, Hackam DJ. Activated Macrophages Inhibit Enterocyte Gap Junctions via the Release of Nitric Oxide. Am J Physiol Gastrointest Liver Physiol. 2007 Nov 1; [Epub ahead of print]
Leaphart CL, Cavallo J, Gribar SC, Cetin S, Li J, Branca MF, Dubowski TD, Sodhi CP, Hackam DJ. A critical role for TLR4 in the pathogenesis of necrotizing enterocolitis by modulating intestinal injury and repair. J Immunol. 2007 Oct 1;179(7):4808-20.
Mi Q, Swigon D, Rivière B, Cetin S, Vodovotz Y, Hackam DJ. One-dimensional elastic continuum model of enterocyte layer migration. Biophys J. 2007 Dec 1;93(11):3745-52. Epub 2007 Aug 17.
