University of Pittsburgh Department of Cell Biology

  • Research

    The endoplasmic reticulum (ER) is the first compartment of the secretor pathway. Plasma membrane receptors, ion channels, hormones and secreted enzymes are few examples of proteins which are being processed and sorted for vesicular transport in the ER. Mistakes in sorting lead to the development of variety of diseases, ranging from hemochromatosis, cystic fibrosis or hereditary emphysema to Pelizaeus-Merzbacher or Alzheimer's neurodegeneration. Viruses such as the cytomegalovirus, HIV-1 Epstein-Barr and many others manipulate ER sorting to evade immune surveillance, a specialized function of the compartment. Dr. Aridor is utilizing a variety of molecular biochemical and cellular techniques to unravel the molecular basis of ER sorting.

  • Publications

    1. Kimberly R. Long*, Yasunori Yamamoto*, Adam L. Baker, Simon C. Watkins, Carolyn B. Coyne, James F. Conway and Meir Aridor (2010) Sar1 Assembly Regulates Membrane Constriction and ER export. J. Cell Biol. 12;190(1):115-28.
    2. Béla Z. Schmidt, Rebecca J. Watts, Meir Aridor and Raymond A. Frizzell (2009). Cysteine String Protein promotes proteasomal degradation of CFTR by increasing its interaction with CHIP and promoting CFTR ubiquitylation. J. Biol. Chem. 13; 284(7): 4168-78.
    3. M. Aridor and K. N. Fish (2009) Selective Targeting of ER Exit Sites Supports Axon Development. Traffic 10 (11): 1669-84.
    4. Aridor M. (2007) Visiting the ER: The Endoplasmic Reticulum as a target for therapeutics in traffic related diseases. Advanced Drug Delivery Reviews 10;59(8):759-81.
    5. G. M. Mueller, O. B. Kashlan, J. B. Bruns, A. B. Maarouf, M. Aridor, T. R. Kleyman and R. P. Hughey (2007) Epithelial sodium channel exit from the endoplasmic reticulum is regulated by a signal within the carboxyl cytoplasmic domain of the a subunit J. Biol. Chem. In press.
    6. T. Iinuma, A. Shiga, K. Nakamoto, M. B. O?Brien, M. Aridor, N. Arimitsu, M. Tagaya, and K. Tani (2007) Mammalian Sec16/p250 plays a role in membrane traffic from the endoplasmic reticulum. J. Biol. Chem. 15;282(24):17632-9.
    7. A. Blumental-Perry, C.J. Haney, K.M. Weixel, S.C. Watkins, O.A. Weisz, and M. Aridor (2006). Phosphatidylinositol 4-Phosphate Formation at ER Exit Sites Regulates ER Export. Developmental Cell 11, 671-682
    8. Aridor M., Guzic, A.K., Bielli, A. and Kenneth N. Fish (2004) Endoplasmic Reticulum Export Site Formation and Function in Dendrites J. Neuroscience 24; 3770-3776
    9. Bielli A, C.J. Haney, G. Gabreski, S. C. Watkins, S. I. Bannykh and M. Aridor (2005) Regulation of Sar1 N-terminus by GTP Binding and Hydrolysis Promotes Membrane Deformation to Control COPII Vesicle Fission. J. Cell Biol. 171: 919-24.
    10. H. Zhang, B. Z. Schmidt, F. Sun, S. B. Condliffe, R.T. Youker, J. L. Brodsky, M. Aridor and R. A. Frizzell (2006) Cysteine String Protein monitors late steps in CFTR biogenesis J. Biol. Chem. 81: 11312-21.
    11. K. M. Weixel, A. Blumental-Perry, S. C. Watkins, M. Aridor, and O. A. Weisz, (2005) Distinct Golgi Populations of Phosphatidylinositol 4-Phosphate Regulated by Phosphatidylinositol 4-Kinases J. Biol. Chem 280(11):10501-8
    12. P. Pathre, K. Shome, A. Blumental-Perry, A. Bielli , C.J. Haney, S Alber, S. Watkins, G. Romero, and M. Aridor (2003) Activation of Phospholipase D by the Small GTPase Sar1 Is Required to support COPII Assembly and ER Export. EMBO J. 22: 4059-4069
    13. Romero G. Shome K. and Aridor M. (2005) Assay and measurment of PLD activation by Sar1 Method in Enzymology 404:108-15.
    14. W. Shimoi, I. Ezawa, K. Nakamoto, S. Uesaki, G. Gabreski, M. Aridor, Akitsugu Yamamoto, Masami Nagahama, Mitsuo Tagaya, and Katsuko Tani (2005) p125 Is Localized in Endoplasmic Reticulum Exit Sites and Involved in Their Organization J. Biol. Chem 18;280(11):10141-8

     

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